Radiolab
My tastes in podcasts have changed a lot in the past year, going from shoddy immature conversation to high production infotainment. The peak of this came late last year when I discovered NPR. Radiolab quickly rose as the cream of the crop and remains in my top 3 podcasts.
Hosted by Jad Abumrad and Robert Krulwich, Radiolab provides top notch journalism with scientific roots. This may sound a bit heavy, but Radiolab doesn't necessarily aim to educate so much as entertain. From the genocide of goats in the Galapagos to the mysterious balloon bombs on the eastern coast of USA, Radiolab digs up fascinating true stories and explain the workings being the scenes.
I became obsessed with the podcast, and quickly ate through over a hundred episodes in the period of weeks. It got to the point where I would listen to 6-7 episodes a day at work, beating information into my brain at an alarming rate. I am thinking that I may go over the catalogue again as the side effect of listening to Radiolab is that you seem instantly more smart and interesting by reciting show factoids.